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Genomic structural variations contribute to inform prognosis in patients with cytogenetically normal acute myeloid leukemia - Blood Cancer Journal
Abstract Cytogenetic and genomic profiling of acute myeloid leukemia (AML) guides personalized treatment according to ELN2022 recommendations. However, marked outcome variability persists among cytogenetically normal (CN-) patients, representing an unmet clinical need. We used long-read whole-genome sequencing to interrogate the prognostic significance of structural variations (SVs) in a prospective cohort of 162 intensively treated CN-AML patients.
A Novel, Ruxolitinib‐Sensitive, CCDC6::JAK2 Fusion Gene in a Patient With Atypical, JAK2 Unmutated, Polycythemia Vera‐Like, Myeloproliferative Neoplasm
To the Editor, The majority of patients with classic myeloproliferative neoplasms (MPNs) harbor driver mutations [1] in JAK2 [2], CALR [3], and MPL [4]; a few are “triple negative” or have non-canonical mutations [5]. Outside classical forms, rare genetic abnormalities are described in unique MPN variants, as the category of “Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase fusion genes” [6, 7].
Correction: A novel approach for highly sensitive and rapid identification of HMGA2 submicroscopic deletions in myeloproliferative neoplasms - Leukemia
Correction to: Leukemia https://doi.org/10.1038/s41375-025-02678-4, published online 14 July 2025 In this article the author’s name Niccolò Bartalucci was incorrectly written as Bartalucci Niccolò. The original article has been corrected.
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