Barbara Schoepp-Cothenet

1 Introduction The marine sulfur cycle plays a central role in maintaining the ocean's redox balance and is driven by the multiple oxidation states that sulfur can adopt. Hydrothermal vent ecosystems, which are widespread on the seafloor, are particularly important for the biogeochemical sulfur cycle (Dick 2019).

Communication PDF ShareShare Abstract De Novo metalloprotein design assesses the relationship between metal active site architecture and catalytic reactivity. Herein, we use an α‐helical scaffold to control the iron coordination geometry when a heme cofactor is allowed to bind to either histidine or cysteine ligands, within a single artificial protein. Consequently, we uncovered a reversible pH‐induced switch of the heme axial ligation within this simplified scaffold.

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