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Barbara Taskinen on Muck Rack

Barbara Taskinen

As seen in: The Journal of Biological Chemistry
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Articles

Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase

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By Barbara Taskinen, Evandro Ferrada, Douglas M. Fowler
| The Journal of Biological Chemistry Verified
Stringent regulation of tyrosine kinase activity is essential for normal cellular function. In humans, the tyrosine kinase Src is inhibited via phosphorylation of its C-terminal tail by another kinase, C-terminal Src kinase (Csk). Although Src and Csk orthologs are present across holozoan organisms, including animals and protists, the Csk–Src negative regulatory mechanism appears to have evolved gradually.
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Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase

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By Douglas M. Fowler, Barbara Taskinen, Evandro Ferrada
| The Journal of Biological Chemistry Verified
Stringent regulation of tyrosine kinase activity is essential for normal cellular function. In humans, the tyrosine kinase Src is inhibited via phosphorylation of its C-terminal tail by another kinase, C-terminal Src kinase (Csk). While Src and Csk orthologs are present across holozoan organisms, including animals and protists, the Csk-Src negative regulatory mechanism appears to have evolved gradually.
Open in Who Shared Issue with article?
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