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Barbora Boleslavska on Muck Rack

Barbora Boleslavska

As seen in: Nature, Cell Press
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Articles

Distinct mechanisms of replication stress induced by oncogenic RAS and cyclin E1 converge on R-loop-dependent fork reversal

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By Anna Oravetzova, Markéta Dvořáková, Martin Andrs, Margarita Sobol, Kaustubh Shukla, Barbora Boleslavska, Vinicio Rosano, Christiane König, Hana Hanzlikova, Libor Macurek, Jana Dobrovolna, Pavel Janscak, Anca-Irina Mihai, Anton Zuev, Jiri Prokes
| Nature Verified
Abstract Activated oncogenes elicit genomic instability by inducing DNA replication stress. Here we show that replication fork reversal and chromosome mis-segregation induced by oncogenic RAS (HRASV12) or cyclin E1 overexpression are largely caused by co-transcriptional RNA:DNA hybrids (R-loops) formed during S-phase.
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Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

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By Czech Republic, Nagaraja Chappidi, Zuzana Nascakova, Barbora Boleslavska
| Cell Press Verified
Highlights • R-loop-induced fork stalling is followed by MUS81-dependent replication restart • RECQ5 mediates the switch from fork stalling to restart by suppressing fork reversal • Restart of R-loop-stalled forks is mediated by fork cleavage and religation • Restart of R-loop-stalled forks requires reactivation of transcription Summary Formation of co-transcriptional R-loops underlies replication fork stalling upon head-on transcription-replication encounters.
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