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Barbora Knotkova on Muck Rack

Barbora Knotkova

As seen in: BioRxiv, Cell Press
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Articles

The core MICOS complex subunit Mic60 has been substituted by two cryptic mitofilin-containing proteins in Euglenozoa

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By Shaghayegh Sheikh, Barbora Knotkova, Corinna Benz, Marek Eliáš
| BioRxiv
Abstract Cristae enclose respiratory chain protein complexes, making them the bioenergetic subcompartments of mitochondria. The MICOS complex is among the inducers of sharp membrane curvature needed for crista formation. Resembling the respiratory chain complexes, MICOS is organized around a core protein, the mitofilin–domain bearing Mic60, that was inherited from the alphaproteobacterial progenitor of mitochondria.
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