Barbro Kahl-Knutson

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Med. Chem. 2023, XXXX, XXX * Fredrik R. Zetterberg Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg, Sweden *Email: FZ@galecto.com. Phone: +46 763240495.

Some complex plant-derived polysaccharides, such as modified citrus pectins and galactomannans, have been shown to have promising anti-inflammatory and anti-cancer effects. Most reports propose or claim that these effects are due to interaction of the polysaccharides with galectins because the polysaccharides contain galactose-containing side chains that might bind this class of lectin.

Author contributions: Fluorescence anisotropy and turbidimetry studies were performed by BK, JS and AL. Galectin-3-induced hemagglutination studies were done by JS and BK. JS and SO performed the in vitro vesical damage studies. MA, RAF and AAK produced some of the pectin- and galactomannan samples analyzed in the study. UJN and co-workers synthesized the fluorescent saccharide-probes used in the FA assay. HL designed and supervised the project.