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Barend O.W. Elenbaas on Muck Rack

Barend O.W. Elenbaas

As seen in: The Journal of Clinical Investigation
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Articles

Human IAPP is a contributor to painful diabetic peripheral neuropathy

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By Sabine Versteeg, Elisabeth M. Brakkee, J. Henk Coert, Judith Prado, C. Erik Hack, Niels Eijkelkamp, Mohammed M.H. Albariqi, Barend O.W. Elenbaas, Jo W.M. Höppener
| The Journal of Clinical Investigation
Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), which forms pathogenic aggregates that damage pancreatic islet β cells in T2DM, is involved in T2DM-associated peripheral neuropathy. In vitro, hIAPP incubation with sensory neurons reduced neurite outgrowth and increased levels of mitochondrial reactive oxygen species.
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