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Baris Bingol

As seen in: Cell Press
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Articles

Reactive oxygen species control protein degradation at the mitochondrial import gate

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By Rachael McMinimy, Andrew G. Manford, Christine Gee, Srividya Chandrasekhar, Gergey Alzaem Mousa, Joelle Chuang, Lilian Phu, Karen Shih, Christopher M. Rose, John Kuriyan, Baris Bingol, Michael Rape
| Cell Press Verified
Keywords ubiquitin proteasome reductive stress response TOM complex electron transport chain mitochondria FEM1B Introduction Toxins, protein aggregates, or mutations in metabolic pathways can lead to an accumulation of reactive oxygen species (ROS).1,2 Such pathological ROS damage proteins, lipids, and nucleic acids, which compromises genome or membrane integrity3,4,5,6 and has been associated with aging, cancer, and neurodegenerative disease.1,7,8 Oxidative stress responses help cells...
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