Baris Karadas
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Intentional Dexketoprofen Overdose During Pregnancy: Maternal and Fetal Outcomes in Three Cases
1 Introduction Dexketoprofen trometamol is the S(+)-enantiomer of ketoprofen, a propionic acid-derivative nonsteroidal anti-inflammatory drug (NSAID). Its analgesic, anti-inflammatory, and antipyretic effects are mediated by inhibiting cyclooxygenase-1 and cyclooxygenase-2, thereby suppressing prostaglandin synthesis. Compared with racemic ketoprofen, the use of a single active enantiomer reduces the effective dose by approximately 50% and simplifies the pharmacokinetic profile (Barbanoj et al.
Pregnancy outcomes following maternal GLP-1 receptor agonist exposure: a systematic review and meta-analysis
Abstract The objective of this systematic review and meta-analysis was to assess the risk of any and major congenital malformations and other adverse pregnancy outcomes following maternal exposure to glucagon-like peptide-1 receptor agonists during the periconceptional period and pregnancy. We conducted a systematic literature search of the PubMed, MEDLINE, Embase, Web of Science, and Reprotox electronic databases from inception through January 2026.
In vitro effect of hyoscine‐N‐butyl bromide and diclofenac sodium in human tuba uterina
1 INTRODUCTION Female infertility is one of the common gynaecological problems.
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