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Conflicts of Interest The authors declare no conficts of interest. Data Availability Statement Data will be made available on request. Supporting Information Filename Description cmdc70175-sup-0001-SuppData-S1.pdf1 MB Supplementary Material References 1, , , et al., “Synthesis of Dihydropyrazole Sulphonamide Derivatives that Act as Anti-Cancer Agents through COX-2 Inhibition,” Pharmacological Research 104 (2016): 86–96, https://doi.org/10.1016/j.phrs.2015.12.025.

COX Cyclooxygenase EGFR Epidermal growth factor receptor GBM Glioblastoma multiforme IC50 The half-maximal inhibitory concentration p38MAPK p38 Mitogen-activated protein kinase SD Standart Deviation 1 Introduction Cyclooxygenase (COX) enzymes are well-established targets in the treatment of pain and inflammation [1].