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Evren Önay Uçar on Muck Rack

Evren Önay Uçar

As seen in: Nature, Wiley Online Library
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Articles

In silico-guided synthesis and cytotoxic evaluation of novel thiazolidin-4-one derivatives on glioblastoma cell lines

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By Nahide Gulsah Deniz, Cigdem Sayil, Evren Önay Uçar, Abdelkader Chouaih, Farah Chafika Kaouche, Gülsima Arik, Nazli Arda
| Nature Verified
Abstract This study presents the synthesis and characterization of two thiazolidin-4-one derivatives (7a and 7b) and the in silico-guided biological evaluation of two novel thiazolidin-4-one derivatives, 7a and 7b for their cytotoxic activity against glioblastoma cells.
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Targeting Inflammatory and Oncogenic Pathways: Cyclooxygenase‐2, Epidermal Growth Factor Receptor, and p38 Mitogen‐Activated Protein Kinase Inhibition by Pyrazolone Derivatives

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By Zafer Şahin, Evren Önay Uçar, Barkın Berk
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conficts of interest. Data Availability Statement Data will be made available on request. Supporting Information Filename Description cmdc70175-sup-0001-SuppData-S1.pdf1 MB Supplementary Material References 1, , , et al., “Synthesis of Dihydropyrazole Sulphonamide Derivatives that Act as Anti-Cancer Agents through COX-2 Inhibition,” Pharmacological Research 104 (2016): 86–96, https://doi.org/10.1016/j.phrs.2015.12.025.
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Targeting Inflammatory and Oncogenic Pathways: Cyclooxygenase‐2, Epidermal Growth Factor Receptor, and p38 Mitogen‐Activated Protein Kinase Inhibition by Pyrazolone Derivatives

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By Evren Önay Uçar, Zafer Şahin, Barkın Berk
| Wiley Online Library Verified
COX Cyclooxygenase EGFR Epidermal growth factor receptor GBM Glioblastoma multiforme IC50 The half-maximal inhibitory concentration p38MAPK p38 Mitogen-activated protein kinase SD Standart Deviation 1 Introduction Cyclooxygenase (COX) enzymes are well-established targets in the treatment of pain and inflammation [1].
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