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Barry R. O’Keefe on Muck Rack

Barry R. O’Keefe

As seen in: Nature, Cell Press
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Articles

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma - Nature Communications

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By Yong Kim, Berkley Gryder, Megan L. Peach, Jack F. Shern, Silvia Pomella, Benjamin Z. Stanton, David Milewski, Raj Chari, Hsien-Chao Chou, Dominic P. Esposito, Lisa Jenkins, Jun S. Wei, Barry R. O’Keefe, Robert Hawley, Joshua T. Kowalczyk
| Nature Verified
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell line that monitors PAX3-FOXO1 transcriptional activity identifying a hitherto uncharacterized compound, P3FI-63. RNA-seq, ATAC-seq, and docking analyses implicate histone lysine demethylases (KDMs) as its targets.
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Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs

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By Girma M. Woldemichael, Barry R. O’Keefe
| Cell Press Verified
Fusion products with the ETS family of transcription factors play critical roles in the etiology of several cancers. In this issue of Structure, Hou et al., 2020 Hou C. Mandal A. Rohr J. Tsodikov O.V. Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure. 2020; 29 (): 404-412 provide insight into allosteric mechanisms by which mithramycin and its analogs perturb protein-DNA interactions in higher-order complexes at a DNA enhancer site.
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