Barry Richmond

Abstract Recent advances in molecular tools have changed how researchers approach selective neural modulation, especially in rodent models where germline modifications and viral vector delivery are readily optimized. However, these tools have not advanced as rapidly for nonhuman primates, despite critical need for translational gene therapy models. A key barrier is targeting specific neuronal populations in the larger primate brain with cell-type and circuit specificity.

Abstract Primates can rapidly categorize images by visual feature similarity. We previously showed that inferior temporal cortex (IT) subregions TEO and TE contribute to visual categorization to differing extents. To investigate the neural plasticity underlying visual categorization, we recorded simultaneously from both areas while two male monkeys learned a visual categorization task.

Neural Correlates of Category Learning in Monkey Inferior Temporal Cortex Jonah E. Pearl, Narihisa Matsumoto, Kazuko Hayashi, Keiji Matsuda, Kenichiro Miura, Yuji Nagai, Naohisa Miyakawa, Takafumi Minamimoto, Richard C. Saunders, Yasuko Sugase-Miyamoto, Barry J. Richmond, Mark A. G. Eldridge Journal of Neuroscience 4 December 2024, 44 (49) e0312242024; DOI: 10.1523/JNEUROSCI.0312-24.2024