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Bart AG

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Articles

CYP3A4 and CYP3A5: the crucial roles in clinical drug metabolism and the significant implications of genetic polymorphisms

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By Scott EE, Ahmad FJ, Lee JS, Bart AG
| PeerJ
Cytochrome P450 (CYP450) is the most significant phase I drug metabolizing enzyme in the human body, and approximately 75–90% of commonly utilized clinical drugs are metabolized by CYP450 (Lee et al., 2024; Zhou, Liu & Chowbay, 2009). Currently, 57 CYP-encoding genes and 58 pseudogenes are known to exist on human chromosomes, which can be further divided into 18 families and 43 subfamilies based on amino acid sequence similarity (Zhao et al., 2021b).
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