Bart Ferwerda

Abstract Pneumococcal meningitis is the most common form of bacterial meningitis, with high case fatality rates. Bacterial genetics influence disease severity, but the underlying mechanisms remain poorly understood. Here, we evaluated top variants from a genome-wide association study (GWAS) linking Streptococcus pneumoniae genetic variation to disease outcome. Fifteen S.

Levodopa is one of the most commonly administered therapies for Parkinson's disease (PD), particularly to treat motor symptoms.1 However, as the disease progresses and patients are exposed to long-term levodopa therapy, a significant proportion develops levodopa-induced dyskinesia (LID), a debilitating side effect characterized by involuntary, uncontrolled, and often choreiform movements.2 LID is estimated to affect ~40% to 50% of PD patients within 4 to 6 years of initiating levodopa...

Abstract Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown.