John Lees on Muck Rack

John Lees

As seen in: British Journal of Cancer, Nature, The Guardian, Daily Express, Daily Star (UK), Metro (UK), Harvard Business Review, Phys.org, Science Magazine, CBR and
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Articles

LacR and TrxB are key virulence factors involved in pneumococcal meningitis as identified by a genome-wide association study

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By Rutger Koning, Kin Ki Jim, Philip Kremer, Hsueh-Chien Cheng, Bart Ferwerda, Bevika Sewgoolam, Roy Ummels, Maikel Boot, John Lees, Stephen Bentley, Jan-Willem Veening, Christina M.J.E. Vandenbroucke-Grauls, Matthijs C Brouwer, Valery Jaspers, Mans Perez, Diederik van de Beek
| Nature Verified
Abstract Pneumococcal meningitis is the most common form of bacterial meningitis, with high case fatality rates. Bacterial genetics influence disease severity, but the underlying mechanisms remain poorly understood. Here, we evaluated top variants from a genome-wide association study (GWAS) linking Streptococcus pneumoniae genetic variation to disease outcome. Fifteen S.
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Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - Nature Biotechnology

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By Wei Shen, John Lees, Zamin Iqbal
| Nature Verified
Abstract The size of microbial sequence databases continues to grow beyond the abilities of existing alignment tools. We introduce LexicMap, a nucleotide sequence alignment tool for efficiently querying moderate-length sequences (>250 bp) such as a gene, plasmid or long read against up to millions of prokaryotic genomes.
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Sex, Stress and the Heart: Long-term Cardiovascular Effects of Embryonic Metabolic Disruption

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By John Lees, Stina Berglund, Kerri Smith Verified, Betul Bicici
| biorxiv.org
Abstract Adverse conditions within the embryonic environment can alter embryogenesis, programming systemic physiological changes that may manifest as disease states in adult life. The process of developmental programming represents an important factor underlying cardiometabolic diseases, many of which are leading causes of death globally.
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