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Bart Groenen on Muck Rack

Bart Groenen

As seen in: BioRxiv, AIP Publishing
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Articles

Nucleocytoplasmic transport senses mechanics independently of cell density in cell monolayers.

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By Guillaume Belthier, Bart Groenen, Ignasi Granero-Moya, Marc Molina
| BioRxiv
Abstract Cells sense and respond to mechanical forces through mechanotransduction, which regulates processes in health and disease. In single cells, mechanotransduction involves the transmission of force to the cell nucleus, where it affects nucleocytoplasmic transport (NCT) and the subsequent nuclear localization of transcriptional regulators such as YAP. However, if and how NCT is mechanosensitive in multicellular systems is unclear.
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Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts

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By Dylan Mostert, Robert Passier, Bart Groenen, Leda Klouda
| AIP Publishing
Strain avoidance of CMs in the presence of cFBs is not mediated by paracrine signaling or N-cadherin We next asked what mechanisms are underlying the strain avoidance of CMs when in co-culture with a threshold value of cFBs. In particular, we wondered if the observed effect could be explained by paracrine signaling of the cFBs or by direct cell–cell communication via adherens junctional protein N-cadherin.
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