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Undetectable Hydroxyurea Levels in the Majority of Sickle Cell Disease Patients, Especially in Young Children
1 Introduction Sickle cell disease (SCD) is a chronic, multi-systemic disease that significantly impacts both patients' and global health. SCD is caused by autosomal recessive mutations in the HBB gene and is characterized by chronic hemolytic anemia, recurrent painful vaso-occlusive ischemic events (VOE), and systemic inflammation [1-3]. These processes contribute to progressive organ damage and reduce life expectancy in patients with SCD.
Effect of Hematopoietic Cell Transplantation on Inflammatory and Angiogenic Plasma Proteins in Sickle Cell Disease
ANGPT-1 angiopoietin-1 ANGPT-2 angiopoietin-2 CD200R1 OX-2 membrane glycoprotein (CD200, MOX1) cell surface glycoprotein CD200 receptor 1 CXCL1 growth-regulated alpha protein CXCL5 C-X-C motif chemokine 5 CXCL6 C-X-C motif chemokine 6 EGLN1 Egl nine homolog 1 EPO erythropoietin G-CSF granulocyte colony-stimulating factor G-CSFR granulocyte colony-stimulating factor receptor IL-10 interleukin-10 IL-18 interleukin-18 IL-1RN interleukin-1 receptor antagonist protein IL-1β interleukin-1 beta IL-6...
Hematopoietic cell transplantation for older acute myeloid leukemia patients in first complete remission: results of a randomized phase III study
Abstract External IDs PubMed 39113672
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