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Articles

Novel oxygenscan parameters differentiate unique hemolytic and inflammatory profiles associated with sickle cell disease genotypes

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By Amira Idrizovic, Marissa J.M. Traets, Sigrid van der Veen, Emmanuel Adu, Mickaël Marin, Emmanuelle Bourdelier, Elisabetta Mezzalira, Betzabel García, Santiago Zazo, Juan Parras, Patricia Alonso De Apellániz, Cesare Rollo, Tiziana Sanavia, Ricard López Verified, Montserrat Torrent, Bart J. Biemond, Erfan Nur, Karin J. Fijnvandraat, Anita Rijneveld, Marjon H. Cnossen, Aida S. Kidane, Nicolas Bourbeau Hébert, Maria Paola Boaro, Slimane Allali, Anna Ruiz-Llobet, Federico Álvarez, Piero Fariselli, Raffaella Colombatti, Pablo Bartolucci, Mariane de Montalembert, Richard van Wijk, Minke A.E. Rab, Anna Collado Gimbert, Sara Reidel, Mirco D’Agnolo, David Beneitez, Marta García Bernal, Griselda Vallès-Cardona, Saskia EM Schols, Caroline Le Van Kim, Eduard J. van Beers
| Nature Verified
Abstract Sickle cell disease (SCD) is caused by hemoglobin S, which alters red blood cells (RBCs) rheological properties leading to vaso-occlusion and chronic hemolysis, the main hallmarks of the disease. They drive the broad clinical spectrum of SCD, including acute complications and progressive organ damage. Oxygen gradient ektacytometry (oxygenscan) is a functional assay that measures RBC deformability and sickling tendency during an oxygen gradient.
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