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Bart Liefers on Muck Rack

Bart Liefers

As seen in: Nature, JAMA (The Journal of the American Medical Association), British Journal of Ophthalmology, The Lancet, American Journal of Ophthalmology
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Articles

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

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By Olga Trofimova, Yating Pan, Bart Liefers, Victor A. De Vries, Michael Beyeler, David M. Presby, Dennis Bontempi, Janna Hastings, Caroline C. W. Klaver, Sven Bergmann Verified, Leah Böttger, Sacha Bors, Jose D. Vargas-Quiros, VascX Consortium
| Nature Verified
Abstract Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years.
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Next-generation phenotyping of inherited retinal diseases from multimodal imaging with Eye2Gene - Nature Machine Intelligence

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By Nikolas Pontikos, William Woof, Siying Lin, Biraja Ghoshal, Bernardo Mendes, Quang Nguyen, Behnam Javanmardi, Alexander Hustinx, Miguel A. Ibarra-Arellano, Ismail Moghul, Mital Shah, Saoud Al-Khuzaei, Siegfried Wagner, Malena Daich Varela, Sagnik Sen, Gunjan Naik, Dayyanah Sumodhee, Nathaniel Kabiri, Jennifer L. Furman, Bart Liefers, Caio Marques, Yu Fujinami-Yokokawa, Alison Hardcastle, Birgit Lorenz, Juliana M. Sallum, Susan Downes, Frank G. Holz, Konstantinos Balaskas, Andrew Webster, Omar A. Mahroo, Peter Krawitz, Advaith Veturi
| Nature Verified
Abstract Rare eye diseases such as inherited retinal diseases (IRDs) are challenging to diagnose genetically. IRDs are typically monogenic disorders and represent a leading cause of blindness in children and working-age adults worldwide. A growing number are now being targeted in clinical trials, with approved treatments increasingly available. However, access requires a genetic diagnosis to be established sufficiently early.
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Deep-learning automated quantification of longitudinal OCT scans demonstrates reduced RPE loss rate, preservation of intact macular area and predictive value of isolated photoreceptor degeneration in geographic atrophy patients receiving C3 inhibition tr…

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By Sophie Glinton, Veronika Lipkova, Livia Faes, Bart Liefers
| British Journal of Ophthalmology
http://orcid.org/0000-0003-2852-6912Dun Jack Fu1, Sophie Glinton1, http://orcid.org/0000-0001-5903-2996Veronika Lipkova1, Livia Faes1, Bart Liefers1,2, Gongyu Zhang1, Nikolas Pontikos1, Alex McKeown3, Lukas Scheibler3, http://orcid.org/0000-0001-8682-4067Praveen J Patel1, Pearse A Keane1, Konstantinos Balaskas1,4 1NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL, Institute of Ophthalmology, London, UK 2Department of Ophthalmology, Erasmus University Medical...
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