Bart M. Vanaudenaerde

Abstract Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types across 983 individuals in the Genotype-Tissue Expression cohort.

Abstract The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS exposure in fully differentiated primary human bronchial epithelial cells (phBECs). Following pathway enrichment analysis, we identified nuclear protein 1 (NUPR1) as a candidate regulator of epithelial stress responses.

Results and discussion Bastacky and Goerke, using low-temperature SEM, suggested that a continuous thin liquid film coats the alveolar walls and extends through the interalveolar pores.30 Upon inhalation, the alveoli expand, potentially stretching the pores and thinning the film. However, imaging such structures under dynamic conditions remains challenging.