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Bart Rose J on Muck Rack

Bart Rose J

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Impact of mini-driver genes in the prognosis and tumor features of colorectal cancer samples: a novel perspective to support current biomarkers

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By Byrne CJ, Scott SN, Bart Rose J, Borgan Rnulf
| PeerJ
Putative mini-driver genes are associated with high mutation rates In order to assess the impact of mini-drivers on tumoral progression, we analyzed the polygenic effect of 159 genes selected from the previous step. Our goal was to identify which of these genes were associated with high mutation rates. As shown in Fig. 3, we found that 60 genes had a significantly higher TMB when mutated compared to their respective wild-type group, with an increase ranging from 5.4–8.7-fold (p-value < 10−5).
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