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Bart Staker on Muck Rack

Bart Staker

As seen in: Nature, The Journal of Biological Chemistry
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Articles

Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor - Nature Communications

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By Andrew Fuller, Kevin P. Battaile, Bart Staker
| Nature Verified
Abstract Acetyl-CoA synthetases (Acs) have emerged as drug targets for the treatment of cancer, metabolic diseases as well as fungal and parasitic infections. Although a variety of small molecule Acs inhibitors have been discovered, the systematic optimization of these molecules has been slowed by a lack of structural information regarding their mechanism of inhibition.
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Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens - Communications Biology

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By Michael Fenwick, Phillip Pierce, Ying Peng, Ellen Wallace, Isabelle Phan, Bart Staker, Wulf Blankenfeldt, Rolf Müller, Thomas Edwards, Logan M. Tillery, Amy E. DeRocher
| Nature Verified
Abstract Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of Escherichia coli DNA pol III). It was previously shown to inhibit the Mycobacterium tuberculosis β-clamp with remarkably high affinity and selectivity – the peptide lacks any interaction with the human sliding clamp.
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ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

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By Sridhar Prasad, Saurabh Menon, Paul Towler, Bart Staker
| The Journal of Biological Chemistry Verified
Paul Towler‡, Bart Staker§, Sridhar G. Prasad§¶, Saurabh Menon‡, Jin Tang∥, Thomas Parsons∥, Dominic Ryan‡, Martin Fisher‡, David Williams‡, Natalie A. Dales‡, Michael A. Patane‡ and Michael W.
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