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Barth D. Grant on Muck Rack

Barth D. Grant

As seen in: Nature, Cell Press
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Articles

Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers | Nature Communications

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By Meghan Lee Arnold, Rebecca Androwski, Ryan J. Guasp, Barth D. Grant
| Nature Verified
Abstract Toxic protein aggregates can spread among neurons to promote human neurodegenerative disease pathology. We found that in C. elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are required cell-autonomously for efficient production of neuronal exophers, giant vesicles that can carry aggregates away from the neuron of origin. The C.
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By Xue W Mei, Amber R. Krauchunas, Julie Zhouli Ni, Diane C. Shakes, Andrew Singson, Katherine A. Maniates, A’maya Looper, Marina Druzhinina, Sunny Dharia, Gunasekaran Singaravelu, Sam Guoping Gu, Barth D. Grant
| Cell Press Verified
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