Bartomeu Massuti
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Phase II Trial of Atezolizumab Combined With Carboplatin and Pemetrexed for Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer With Untreated Brain Metastases (Atezo-Brain, GECP17/05) | Journal of Clinical Oncology
Lung cancer is the most common solid tumor to metastasize to the CNS and about one quarter of patients diagnosed with stage IV non–small-cell lung cancer (NSCLC) have brain metastases at diagnosis.1 Historically, whole-brain radiotherapy (WBRT) had been the cornerstone of treatment for brain metastases in patients with advanced NSCLC, especially when stereotactic radiosurgery (SRS) and surgery were not feasible or indicated.
Phase II Clinical Trial with Metronomic Oral Vinorelbine and Tri-weekly Cisplatin as Induction Therapy, Subsequently Concomitant with Radiotherapy (RT) in Patients with Locally Advanced, Unresectable, Non-Small Cell Lung Cancer (NSCLC). Analysis of Surviv
Highlights • New drug schemes are needed for unresectable stage III NSCLC • Metronomic chemotherapy based on oral vinorelbine and cisplatin exhibits low toxicity • ctDNA analysis can identify the subgroup of patients who might benefit from this treatment Abstract Background Little progress has been achieved in non-small cell lung cancer (NSCLC) patients with unresectable stage III disease and new drug schemes are warranted.
Cost analysis of the management of brain metastases in patients with advanced ALK+ NSCLC: alectinib versus crizotinib
Practice points The annual cost derived from the management of advanced ALK+ NSCLC patients with CNS metastases compared with patients without CNS metastases was estimated. An expert panel formed by medical oncologists estimated the healthcare resources consumption of each type of patient (with vs without CNS metastases).
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