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Bartosz Karaszewski on Muck Rack

Bartosz Karaszewski

As seen in: PLOS ONE, BioRxiv
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Articles

Differential expression and modulation of EBI2 and 7α,25-OHC synthesizing (CH25H, CYP7B1) and degrading (HSD3B7) enzymes in mouse and human brain vascular cells

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By Fionä Caratis, Bartosz Karaszewski, Ilona Klejbor, Collegium Medicum
| PLOS ONE
Loading metrics Open Access Peer-reviewed Research Article Citation: Caratis F, Karaszewski B, Klejbor I, Furihata T, Rutkowska A (2025) Differential expression and modulation of EBI2 and 7α,25-OHC synthesizing (CH25H, CYP7B1) and degrading (HSD3B7) enzymes in mouse and human brain vascular cells. PLoS ONE 20(2): e0318822.
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Systemic inflammation modulates the levels of EBI2 and 7α,25-OHC synthesizing (CH25H, CYP7B1) and degrading (HSD3B7) enzymes in brain microvascular cells

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By Fionä Caratis, Bartosz Karaszewski, Ilona Klejbor, Tomomi Furihata
| BioRxiv
Abstract The endogenous ligand for the EBI2 receptor, oxysterol 7α,25OHC, crucial for immune responses, is finely regulated by CH25H, CYP7B1 and HSD3B7 enzymes. Lymphoid stromal cells and follicular dendritic cells within T cell follicles maintain a gradient of 7α,25OHC, with stromal cells increasing and dendritic cells decreasing its concentration. This gradient is pivotal for proper B cell positioning in lymphoid tissue.
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Systemic inflammation differentially modulates the levels of EBI2 and CH25H/CYP7B1 enzymes in the brain microvascular cells.

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By Fionä Caratis, Ilona Klejbor, Tomomi Furihata, Bartosz Karaszewski
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.04.16.537063 Abstract The EBI2 receptor is a major modulator of innate immunity and, together with its ligand, oxysterol 7α,25OHC, has been implicated in several neuroinflammatory and autoimmune diseases. 7alpha,25OHC is synthesised from cholesterol with CH25H and CYP7B1 enzymes and degraded with HSD3B7.
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