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Barun Mahata on Muck Rack

Barun Mahata

As seen in: BioRxiv, The Journal of Biological Chemistry
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Articles

Tailoring a CRISPR/Cas-based Epigenome Editor for Programmable Chromatin Acylation and Decreased Cytotoxicity

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By Jacob Goell, Jing Li, Barun Mahata, Alex J Ma
| BioRxiv
Abstract Engineering histone acylation states can inform mechanistic epigenetics and catalyze therapeutic epigenome editing opportunities. Here, we developed engineered lysine acyltransferases that enable the programmable deposition of acetylation and longer-chain acylations. We show that targeting an engineered lysine crotonyltransferase results in weak levels of endogenous enhancer activation yet retains potency when targeted to promoters.
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Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

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By Barun Mahata, Alan Cabrera, Daniel Brenner, Rosa S Guerra-Resendez
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
Open in Who Shared View Duplicates (700) Issue with article?

Elevated histone H3 acetylation and loss of the Sp1-HDAC1 complex de-repress the GM2-synthase gene in renal cell carcinoma

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By Avisek Banerjee, Barun Mahata, Arjun Dhir, Tapan Mandal
| The Journal of Biological Chemistry Verified
Avisek Banerjee‡, Barun Mahata‡, Arjun Dhir‡, Tapan Kumar Mandal§ and Kaushik Biswas‡1 From the ‡Division of Molecular Medicine, Bose Institute, Kolkata, West Bengal 700 054 India and §Department of Urology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal 700 014 India ↵1 To whom correspondence should be addressed. E-mail: kbiswas_1{at}yahoo.com. Edited by Joel M.
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