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Barun Pradhan on Muck Rack

Barun Pradhan

As seen in: Science Magazine, JoVE- Journal of Visualized Experiments
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Articles

X-chromosome inactivation draws L1 mutagenesis to the human X chromosome

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By Tianyu Zhu, Thomas Cottle, Anna M. Puszynska, Maria E. Ferreiro, Natasha Jansz, Charles Bell, Juan M Botto, Trung Nguyen, Trung Nguyễn, Barun Pradhan, Ana Colomer-Boronat, Diane A. Flasch, Sabrina M. Gericke, Thomas Wilson, Adam Ewing, Sara R. Heras, Francisco J. Sanchez-Luque, Ryan Lister, John Moran, Geoffrey J. Faulkner, Minchun Chen
| Science Magazine Verified
Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary The human X chromosome is exceptionally rich in L1 retrotransposons. These mobile DNA sequences have long been hypothesized to aid X-chromosome inactivation (XCI), which ensures that X-chromosome genes are expressed equally in XX and XY individuals. de los Rios Barreda et al.
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Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

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By Barun Pradhan, Liisa Kauppi
| JoVE- Journal of Visualized Experiments
Cancer Research Unable to load video. Please check your Internet connection and reload this page. If the problem continues, please let us know and we'll try to help. An unexpected error occurred. Please check your Internet connection and reload this page. If the problem continues, please let us know and we'll try to help. Summary This article outlines a simple PCR-based assay to monitor the activity of an active LINE-1 retrotransposon and to map de novo retrotranspositions in a given genome.
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