Bastien Cabarrou
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Terminal T-cell exhaustion predicts tumor control independent of immunotherapy in ovarian cancer
Abstract T-cell exhaustion is typically studied in the context of immune checkpoint blockade, where proliferation and reinvigoration of exhausted cells drives therapeutic responses. However, terminal exhaustion may also represent a marker of chronic tumor-specific activation, raising the possibility that exhausted T cells reflect ongoing endogenous tumor control.
A Multigene Signature Associated with Progression-Free Survival after Treatment for IDH Mutant and 1p/19q Codeleted Oligodendrogliomas
4. Discussion Our study was designed to highlight gene signatures associated with progression-free survival and response to radiotherapy and chemotherapy among patients treated for 1p/19q codeleted ODs. Two of the 68 patients we analyzed had 1p/19q codeleted tumors that were IDH wild-type and would not have been identified under the WHO 2021 classification as ODs. In all likelihood, these two patients actually had diffuse leptomeningeal glioneuronal tumors.
Impact of a comprehensive geriatric assessment on decision‐making in older patients with hematological malignancies
ORIGINAL ARTICLE Marie Garric Corresponding Author garric.m@chu-toulouse.fr orcid.org/0000-0002-4551-6620 Geriatric Department, Internal Medicine and Oncogeriatry Unit, Centre Hospitalier Universitaire de Toulouse, Toulouse, France Correspondence Marie Garric, Geriatric Department, Internal Medicine and Oncogeriatry Unit, Toulouse University Hospital, Place du Docteur Baylac, TSA 40031, 31059, Toulouse Cedex 9, France.
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