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Articles by Beata Ujvari
When effective anticancer therapies are, in fact, destabilizing the tumor’s Group Phenotypic Composition
Abstract Many cancer therapies achieve durable control without complete tumor eradication, suggesting that disrupting tumor organization may be more critical than killing cells. We propose that effective treatments converge by destabilizing the tumor’s Group Phenotypic Composition (GPC), the functional and spatial organization of interacting cell populations. When this organization collapses, tumors lose coherence.
Adaptive cancer therapy: can non-genetic factors become its achilles heel? - Oncogene
Abstract The recurrence of clinically advanced cancers is an evolutionary consequence of standard-of-care chemotherapies generally administered at maximum tolerated doses to kill as many cancer cells as possible. The inevitable appearance of resistance raises the possibility of shifting treatment goals from complete tumor eradication to long-term disease control.
When Do Tumours Develop? Neoplastic Processes Across Different Timescales: Age, Season and Round the Circadian Clock
1 Introduction Neoplasia, defined as an abnormal tissue growth (malignant or not), is a pathology that appeared at the end of the Precambrian period (about a billion years ago) with the appearance of multicellular organisms (Domazet-Loso and Tautz 2010; Ujvari, Roche, and Thomas 2017). It therefore concerns all metazoans, being present in animals from hydras to whales (Domazet-Lošo et al. 2014; Aktipis et al. 2015; Vincze et al. 2022).
The complex effects of modern oncogenic environments on the fitness, evolution and conservation of wildlife species
1 INTRODUCTION There is a growing acknowledgment that wildlife is becoming increasingly vulnerable to cancerous diseases compared to the past (Dujon, Ujvari, & Thomas, 2021; Giraudeau et al., 2018; McAloose & Newton, 2009; Pesavento et al., 2018; Sepp et al., 2019; Ujvari et al., 2018).
A novel perspective suggesting high sustained energy expenditure may be net protective against cancer
A novel perspective suggesting high sustained energy expenditure may be net protective against cancer Mots clés Cancer Energetics Metabolism Sustained energy expenditure Domaines Cancer Endocrinologie et métabolisme Santé publique et épidémiologie Origine : Fichiers éditeurs autorisés sur une archive ouverte Licence : CC BY - Paternité
Manganese Exacerbates Seasonal Health Declines in a Suicidally Breeding Mammal
INTRODUCTION Reproduction is so costly that organisms typically distribute their efforts and offspring over time to accommodate the competing energetic demands of growth and survival, and delay breeding during periods of poor health or environmental stress (Koons et al., 2008; Tuljapurkar, 1990). However, not all species hold back for the future—some invest all resources into a single (usually promiscuous) bout of breeding and then die.
Polyandry and non-random fertilisation maintain long-term genetic diversity in an isolated island population of adders (Vipera berus) - Heredity
Abstract Conservation genetic theory suggests that small and isolated populations should be subject to reduced genetic diversity i.e., heterozygosity and allelic diversity. Our 34 years study of an isolated island population of adders (Vipera berus) in southern Sweden challenges this notion.
Can Energetic Capacity Help Explain Why Physical Activity Reduces Cancer Risk?
Highlights Physical activity substantially reduces the risk of developing cancer. As such, exercise promises to be a powerful preventative measure against cancer. However, if we are to ‘prescribe’ exercise, we should identify how and why exercise affects cancer risk to provide informed prescriptions. We find that high energetic capacity is both a cause and consequence of high sustained activity levels, both at a genetic level and due to training effects.
Evolutionary foundations in cancer biology
offs of this sort may exist for female susceptibility to breast cancer as well, as estrogen response to competitive interac- tions is associated with higher motivation for power (Stan- Many of the examples above ?t neatly into evolution- ary life history theory and its analysis of the trade-offs and keeping one’s body running in tip-top shape) and and caring for offspring) (Stearns 2000).
Infections and cancer: the “fifty shades of immunity” hypothesis
Responses of immune system against proliferation of cancer cells and infections – ], it is nevertheless worth pointing out the primary immune mechanisms involved both in infection process and cancerogenesis. For instance, it has been shown that cancer cells are able to evade immune system through numerous mechanisms in advanced stages of tumor [ , ]. Therefore, we could assume that infections may have a significant role at the beginning of carcinogenesis, i.e. during immunosurveillance.
Is Natural Selection The Answer To The Cancer Riddle?
Essential organs tasked with keeping us alive and reproducing – such as the heart, brain or uterus – may have evolved better protection against cancer than larger and paired organs, we have proposed. In an article published today in the journal Trends in Cancer, we hypothesise humans can more easily tolerate tumours in large or paired organs than in small, critical organs. Therefore the larger organs may have evolved fewer cancer defence mechanisms.
Natural selection may be the answer to the cancer riddle, but can we beat evolution?
Essential organs tasked with keeping us alive and reproducing – such as the heart, brain or uterus – may have evolved better protection against cancer than larger and paired organs, we have proposed. In an article published today in the journal Trends in Cancer, we hypothesise humans can more easily tolerate tumours in large or paired organs than in small, critical organs. Therefore the larger organs may have evolved fewer cancer defence mechanisms.
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