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Beniah Brumbaugh

As seen in: Science Magazine, BioRxiv
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Articles

Full-length premembrane protein is not required for mature Zika virus particle assembly

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By Kimberly A. Dowd, Huaxin Song, Saif Malik, Egan Sanchez, Beniah Brumbaugh, Bryant M. Foreman, Katherine E. Burgomaster, Wei Shi, Lingshu Wang, Natalie Caputo, David Gordon, Cindi L. Schwartz, Bryan Hansen, Adam S. Olia, Mehin Suleiman, Jessica Guyette, Maya Aleshnick, Wing-Pui Kong, Kaitlyn M. Morabito, Yaroslav Tsybovsky, Heather D. Hickman, Barney S. Graham, Elizabeth Fischer, Tongqing Zhou
| Science Magazine Verified
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Proteolytic cleavage of the structural premembrane (prM) protein of flaviviruses such as Zika virus is seen as a defining step in virus particle maturation. Dowd et al. now show that Zika virus particles can assemble without the pr domain of prM, challenging established models of flavivirus generation.
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pr-independent biogenesis of infectious mature Zika virus particles

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By Kimberly A. Dowd, Egan Sanchez, Beniah Brumbaugh
| BioRxiv
Abstract Flavivirus assembly at the endoplasmic reticulum is driven by the structural proteins envelope (E) and premembrane (prM). Here, contrary to the established paradigm for flavivirus assembly, we demonstrate that the biogenesis of flavivirus particles does not require an intact prM nor proteolytic activation. The expression of E preceded by a truncated version of prM (M-E) was sufficient for the formation of non-infectious Zika virus subviral particles and pseudo-infectious reporter virions.
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