Barney S. Graham
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Full-length premembrane protein is not required for mature Zika virus particle assembly
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Proteolytic cleavage of the structural premembrane (prM) protein of flaviviruses such as Zika virus is seen as a defining step in virus particle maturation. Dowd et al. now show that Zika virus particles can assemble without the pr domain of prM, challenging established models of flavivirus generation.
A structure-based mRNA vaccine for Nipah virus in healthy adults: a phase 1 trial
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Abstract Nipah virus (NiV) is a highly pathogenic, zoonotic paramyxovirus with pandemic potential. No licensed vaccines or treatments are available. Therefore, we conducted a phase 1, first-in-human, open-label, dose-escalation trial of a lipid nanoparticle mRNA vaccine, mRNA-1215, encoding a chimeric pre-fusion F (Pre-F) protein linked to glycoprotein G of a NiV Malaysian strain.
By Aurélie Ploquin, Rosemarie Mason, Myra Happe, Alicia Widge, Laura Novik, Ana M. Ortega-Villa, Galina V. Yamshchikov, Ingelise Gordon, Abidemi Ola, Anita Arthur, Floreliz Mendoza, Jamie Saunders, William Whalen, Joanna Utoh, Jennifer Cunningham Verified, Lorin N. Loftus, Ashley Heimann, Katia G. Korzeniwsky, Shayne F. Andrew, Evan R. Lamb, Amelia Thompson, Mary McDonald, Kathryn E. Foulds, Nancy Sullivan, Emily Coates, Rebecca J. Loomis, Barney S. Graham, Karin Bok, Sunny Himansu, Brett Leav, John H Beigel, Mario Roederer, Lesia Dropulic, LaSonji A. Holman, Pamela J. M. Costner, Xioalin Wang, Shruthi Shyam Sunder, Jessica Bahorich, Walla Dempsey
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Nature
Verified
Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem
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Keywords influenza virus broadly neutralizing antibody bnAb hemagglutinin germline-targeting HA stem nanoparticle B cell IGHV1-69 IGHD3-9 Research topic(s) CP: Immunology Introduction Influenza A and B viruses cause seasonal epidemics and hundreds of thousands of hospitalizations and deaths every year.1 Influenza A viruses (IAVs) have also been responsible for four major global pandemics in the last 110 years.
By Sila Ataca, Maya Sangesland, Larance Ronsard, Seyhan Boyoglu-Barnum, Rebecca A. Gillespie, Yaroslav Tsybovsky, Tyler Stephens, Syed M. Moin, Julia Lederhofer, Adrian Creanga, Sarah Andrews, Ralston M. Barnes, Daniel Rohrer, Nils Lonberg, Barney S. Graham, Andrew Ward, Daniel Lingwood, Masaru Kanekiyo
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Cell Reports
Verified
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