Beniamin Krupkin

Correction to: Nature https://doi.org/10.1038/s41586-025-09522-w Published online 17 September 2025 In the version of the article initially published, in Fig. 1b, the exons in the top line depicting the Scn2a allele were flipped and read “3 4 5” and have now been corrected to “5 4 3” in the HTML and PDF versions of the article. About this article Tamura, S., Nelson, A.D., Spratt, P.W.E. et al. Publisher Correction: CRISPR activation for SCN2A-related neurodevelopmental disorders. Nature (2025).

Abstract Most neurodevelopmental disorders with single gene diagnoses act via haploinsufficiency, in which only one of the two gene copies is functional1. SCN2A haploinsufficiency is one of the most frequent causes of neurodevelopmental disorder, often presenting with autism spectrum disorder, intellectual disability and, in a subset of children, refractory epilepsy2.