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Benjamin Barsi-Rhyne on Muck Rack

Benjamin Barsi-Rhyne

As seen in: The Journal of Biological Chemistry
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Articles

Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor

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By Justine Paradis, Adam Officer, Benjamin Barsi-Rhyne
| The Journal of Biological Chemistry Verified
ABSTRACT β-arrestins play a key role in G protein-coupled receptor (GPCR) internalization, trafficking, and signaling. Whether β-arrestins act independently of G protein-mediated signaling has not been fully elucidated. Recent studies using genome editing approaches revealed that whereas G proteins are essential for ERK activation by GPCRs, β-arrestins play a more prominent role in signal compartmentalization.
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