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Presynaptic Nanoscale Components of Retrograde Synaptic Signaling
Keywords Animals, Synaptic Transmission, Receptor, Cannabinoid, CB1, Synapses, Signal Transduction, Presynaptic Terminals, Mice, Endocannabinoids, Dronabinol Abstract While our understanding of the nanoscale architecture of anterograde synaptic transmission is rapidly expanding, the qualitative and quantitative molecular principles underlying distinct mechanisms of retrograde synaptic communication remain elusive.
The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles
Abstract While it is known that endocannabinoids (eCB) modulate multiple neuronal functions, the molecular mechanism governing their release and transport remains elusive. Here, we propose an 'on-demand release' model, wherein the formation of microvesicles, a specific group of extracellular vesicles (EVs) containing the eCB, 2-arachidonoylglycerol (2-AG), is the rate-limiting step.
Presynaptic nanoscale components of retrograde synaptic signaling
Research Article NEUROSCIENCE Benjámin Barti https://orcid.org/0000-0002-1669-2246, Barna Dudok https://orcid.org/0000-0001-5078-0090, [...] , Kata Kenesei https://orcid.org/0000-0001-5711-885X, Miklós Zöldi https://orcid.org/0000-0002-8592-5015, [...] , Vivien Miczán https://orcid.org/0000-0003-0457-4899, Gyula Y.
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