Barna Dudok

Abstract Subthreshold voltage dynamics are essential for neuronal information integration, yet they remain technically challenging to measure in vivo. While genetically encoded voltage indicators are emerging as powerful tools for voltage recording, they lack the sensitivity to detect millivolt-scale subthreshold fluctuations with two-photon microscopy—the method of choice for deep-tissue recording.

Keywords endocannabinoid CB1 receptor behavior hippocampus cholecystokinin interneuron inhibition translational disease brain state Introduction The brain by dry weight is composed mostly of lipids, and endocannabinoids (eCBs) form a major class of lipid-derived information-carrying molecules. eCBs have important roles in a wide range of neuronal phenomena, including appetite regulation, temperature regulation, pain perception, brain development, learning and memory, and motor functions.

Keywords Animals, Synaptic Transmission, Receptor, Cannabinoid, CB1, Synapses, Signal Transduction, Presynaptic Terminals, Mice, Endocannabinoids, Dronabinol Abstract While our understanding of the nanoscale architecture of anterograde synaptic transmission is rapidly expanding, the qualitative and quantitative molecular principles underlying distinct mechanisms of retrograde synaptic communication remain elusive.