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Benjamin Diamond

As seen in: Nature, JAMA Oncology, BioRxiv, The Lancet, ONCOLOGY journal, OncLive, WRVO-FM (Oswego, NY), The Oswegonian, Ladysmith News
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Articles

Myeloma Collection

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By Benjamin Diamond, Dhanvantri Chahar, Michael D. Jain, Alexandra M Poos
| brnw.ch
América de Cali anunció recientemente que el entrenador Alex Escobar se encargará de dirigir al equipo de forma interina en reemplazo del argentino Diego Raimondi, quien salió de la institución escarlata por una crisis de resultados que lo han dejado actualmente en la última posición de la presente Liga BetPlay.
Open in Who Shared Issue with article?

Temporal genomic dynamics shape clinical trajectory in multiple myeloma - Nature Genetics

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By Francesco Maura, Marcella Kaddoura, Linda B. Baughn, Anthony M Cirrincione, Kylee H. Maclachlan, Benjamin Diamond, Patrick Blaney, Lukas John, Ahmet Dogan, Alexander M. Lesokhin, Hartmut Goldschmidt, Elias K. Mai, Gareth Morgan Verified, Shaji Kumar Verified, Saad Usmani, Ola Landgren
| Nature Verified
Abstract Multiple myeloma evolution is characterized by the accumulation of genomic drivers over time. To unravel this timeline and its impact on clinical outcomes, we analyzed 421 whole-genome sequences from 382 patients. Using clock-like mutational signatures, we estimated a time lag of two to four decades between the initiation of events and diagnosis.
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Mutagenic impact and evolutionary influence of radiotherapy in hematologic malignancies

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By Benjamin Diamond, Dhanvantri Chahar, Michael D. Jain, Alexandra M Poos
| BioRxiv
Abstract Ionizing radiotherapy (RT) is a widely used palliative and curative treatment strategy for malignancies. In solid tumors, RT-induced double strand breaks lead to the accumulation of indels, and their repair by non-homologous end-joining has been linked to the ID8 mutational signature in resistant cells. However, the extent of RT-induced DNA damage in hematologic malignancies and its impact on their evolution and interplay with commonly used chemotherapies has not yet been explored.
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