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RNA as a reinforcing node in condensate formation
Get full text access Log in, subscribe or purchase for full access. References 1. Pei, G. ∙ Lyons, H. ∙ Li, P. ... Transcription regulation by biomolecular condensates Nat. Rev. Mol. Cell Biol. 2025; 26:213-236 2. Mathias, K.M. ∙ Liu, Y. ∙ Wan, L. Dysregulation of transcriptional condensates in human disease: mechanisms, biological functions, and open questions Curr. Opin. Genet. Dev. 2024; 86, 102203 3. Sabari, B.R. ∙ Hyman, A.A. ∙ Hnisz, D.
Density transitions in the regulation of transcription
Keywords transcription condensates phase separation density transition higher-order complex emergent property transcriptional burst Introduction Gene activation is a multi-step process that requires the coordination of dozens of factors in space and time.
The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators
Keywords phase separation NUP98 fusion protein biomolecular condensate selective partitioning transcriptional regulation leukemia MLL WDR5 coactivator Get full text access Log in, subscribe or purchase for full access. References 1. Banani, S.F. ∙ Lee, H.O. ∙ Hyman, A.A. ... Biomolecular condensates: organizers of cellular biochemistry Nat. Rev. Mol. Cell Biol. 2017; 18:285-298 2. Shin, Y. ∙ Brangwynne, C.P. Liquid phase condensation in cell physiology and disease Science. 2017; 357, eaaf4382 3.
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