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Articles by Benjamin S. Bleier
Differential targeting of olfactory epithelium and respiratory epithelium in nose-to-brain drug delivery
ABSTRACT Introduction Nose-to-brain drug delivery provides a promising noninvasive route to bypass the blood-brain barrier through direct nasal cavity-brain connections. Therapeutic agents reach the central nervous system via systemic circulation or olfactory/trigeminal nerve pathways.
Effective Nose-to-Brain Delivery of Blood-Brain Barrier Impermeant Anti-IL-1β Antibody via the Minimally Invasive Nasal Depot (MIND) Technique
1. Introduction Click to copy section linkSection link copied! The treatment of central nervous system (CNS) disease is hindered by the blood-brain barrier (BBB), which restricts access to the brain. Neuroinflammation, a key factor in the development and progression of neurodegenerative diseases, poses a significant challenge. In Alzheimer’s disease (AD), for instance, neuroinflammation occurs before amyloid β (Aβ) deposition, highlighting its critical role in disease progression.
Effective Nose-to-Brain Delivery of Blood-Brain Barrier Impermeant Anti-IL-1β Antibody via the Minimally Invasive Nasal Depot (MIND) Technique
1. Introduction Click to copy section linkSection link copied! The treatment of central nervous system (CNS) disease is hindered by the blood-brain barrier (BBB), which restricts access to the brain. Neuroinflammation, a key factor in the development and progression of neurodegenerative diseases, poses a significant challenge. In Alzheimer’s disease (AD), for instance, neuroinflammation occurs before amyloid β (Aβ) deposition, highlighting its critical role in disease progression.
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on the article “Cystatin SN is a potent upstream initiator of epithelial-derived type 2 inflammation in chronic rhinosinusitis.” 2 Cystatin SN is a potent upstream initiator of epithelial-derived type 2 inflammation in chronic rhinosinusitis.
Mechanisms and pathogenesis of chronic rhinosinusitis
This paper is only available as a PDF. To read, Please Download here. Abstract Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways and is historically divided into two main phenotypes: CRS with nasal polyps (NPs) (CRSwNP) and CRS without NPs (CRSsNP).
COVID-19 Vaccines May Not Prevent Nasal SARS-CoV-2 Infection and Asymptomatic Transmission
The pace of COVID-19 vaccine progress has been unprecedented, with >160 programs in preclinical and clinical trials. Clinical outcome measures within the lead candidates completing phase 3 studies are currently focused on safety and prevention of the COVID-19 syndrome.
COVID-19 Vaccines May Not Prevent Nasal SARS-CoV-2 Infection and Asymptomatic Transmission
Current COVID-19 vaccine candidates are administered by injection and designed to produce an IgG response, preventing viremia and the COVID-19 syndrome. However, systemic respiratory vaccines generally provide limited protection against viral replication and shedding within the airway, as this requires a local mucosal secretory IgA response. Indeed, preclinical studies of adenovirus and mRNA candidate vaccines demonstrated persistent virus in nasal swabs despite preventing COVID-19.
‘Smell Training’ Could Help People Who Lost Their Sense of Smell From COVID-19
MICROGEN IMAGES/SCIENCE PHOTO LIBRARY/Getty Images Key Takeaways Loss of smell or a distorted sense of smell is common in COVID-19 patients. Researchers have determined that "smell training" could help people regain their ability to detect scents. Overall, it's unclear how much "smell training" helps. For those who are dealing with a lingering loss of smell after COVID or from another cause, it might be worth a try.
Superior Turbinate Eosinophilia Predicts Olfactory Decline in Patients with Chronic Rhinosinusitis
Background Predicting the postoperative olfactory decline in patients with chronic rhinosinusitis (CRS) remains a significant challenge. Objective The objective of this study was to evaluate patterns of postoperative olfactory function in CRS patients and then explore potential predictors of postoperative olfactory decline. Methods Seventy-six patients with CRS electing endoscopic sinus surgery (ESS) were enrolled in this prospective study.
Oxidative Post-translational Modifications Accelerate Proteolytic Degradation of Calprotectin
Abstract Oxidative post-translational modifications affect the structure and function of many biomolecules. Herein we examine the biophysical and functional consequences of oxidative post-translational modifications to human calprotectin (CP, S100A8/S100A9 oligomer, MRP8/MRP14 oligomer, calgranulins A/B oligomer). This abundant metal-sequestering protein contributes to innate immunity by starving invading microbial pathogens of transition metal nutrients in the extracellular space.
Researchers develop drug delivery technique to bypass blood-brain barrier
Boston, MA, Sep. 10, 2015 Researchers at Massachusetts Eye and Ear/Harvard Medical School and Boston University have successfully prevented the development of Parkinson's disease in a mouse using new techniques to deliver drugs across the naturally impenetrable blood-brain barrier.
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