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Abstract Predicting not just if, but also when, cognitively unimpaired individuals are likely to develop onset of Alzheimerʼs disease (AD) symptoms would be useful to clinical trials and, eventually, clinical practice. Although clock models based on amyloid and tau positron emission tomography have shown promise in predicting the onset of AD symptoms, a model based on plasma biomarkers would be more accessible.
S.E.S. has served on advisory boards and received speaking fees from Eisai and Eli Lilly. She has analyzed data from C2N Diagnostics that was provided to Washington University at no cost. S.E. Schindler has not directly received any research or personal compensation from C2N Diagnostics or any other diagnostics companies. K.K.P., B.S., D.T., and E.G.R. have nothing to disclose.
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Abstract Background Research in transformed, immortalized cell lines indicates the cadherin-related family member 3 (CDHR3) protein serves as a receptor for human rhinovirus C (HRV-C). Similar experiments indicate the CDHR3 coding variant, rs6967330, increases CDHR3 protein surface expression.
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