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Articles by Benjamin Stear
Homo Sapiens Chromosomal Location Ontology: A Framework for Genomic Data in Biomedical Knowledge Graphs - Scientific Data
Abstract The Homo sapiens Chromosomal Location Ontology (HSCLO) is designed to facilitate the integration of human genomic features into biomedical knowledge graphs from releases GRCh37 and GRCh38 at multiple resolutions. HSCLO comprises two distinct versions, HSCLO37 and HSCLO38, each tailored to its respective human genome release.
Positioning Genomic Features in Biomedical Knowledge Graphs using the Homo sapiens Chromosomal Location Ontology for GRCh38 (HSCLO38)
Abstract The Homo sapiens Chromosomal Location Ontology for GRCh38 (HSCLO38) represents a knowledge-graph-ready framework for connecting genomic features at multiple resolutions. We present the methodology behind the development of HSCLO38 and its integration with current genomic standards for application in biomedical research. We explore the performance and scalability of HSCLO38 in specific use cases in handling large-scale genomic data in a biomedical knowledge graph.
Petagraph: A large-scale unifying knowledge graph framework for integrating biomolecular and biomedical data
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Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact
Highlights • Multi-omics analysis and techniques with NASA’s GeneLab platform • The largest cohort of astronaut data to date utilized for analysis • Mitochondrial dysregulation driving spaceflight health risks • NASA Twin Study data validates mitochondrial dysfunction during space missions Summary Spaceflight is known to impose changes on human physiology with unknown molecular etiologies.
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact
Keywords mitochondria lipids spaceflight GeneLab NASA Twin Study NASA Rodent Research Missions microgravity space radiation transcriptomic Introduction Humanity is on the brink of a new era in space exploration, with NASA and international partners committed to returning to the Moon and planned manned missions to Mars (Dawson, 2016). Exposure to space radiation and microgravity are primary hazards to astronauts’ health in long-duration space missions (Garrett-Bakelman et al., 2019).
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