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Berta N. Vazquez on Muck Rack

Berta N. Vazquez

As seen in: Nature, Science Magazine, BioRxiv, Cell Press, Bekia, Dialnet - Universidad de La Rioja, Koax Magazine
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Articles

SIRT2 antagonizes MOF function during mitotic entry

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By Andrea Cimolato, Tahnee Mackensen, Wenqi Pan, Maria Espinosa-Alcantud, Núria Sima, Irene Fernández-Duran, Anna Marazuela-Duque, Gerard Martínez-Cebrián, Anna Guitart-Solanes, Andrés Gámez-García, Paloma Martinez-Redondo, Laia Bosch-Presegué, Berta N. Vazquez, Luis Paños, Joan Bech, Tim Thomas, Marian A. Martínez-Balbás, Anne K. Voss, Marcus Kruger, Lourdes Serrano, Sergi Cuartero, Carolina De La Torre, Alejandro Vaquero, Mireia Olivella
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mitosis entry is tightly regulated by a complex network of mechanisms involving epigenetic modifications, signaling pathways, transcriptional control, and structural changes.
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SIRT7 regulates dosage compensation and safeguards the female X chromosome

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By Nicolás G. Simonet, Joshua K. Thackray, Barry Kesner, Anna Guitart-Solanes, François Serra, Maria Espinosa-Alcantud, Anna Lappala, Laia Marín-Gual, Uri Weissbein, Moritz Bauer, Llorenc Rovirosa, Lourdes Serrano, Bernhard Payer, Aurora Ruiz-Herrera, Berta N. Vazquez, Biola M. Javierre, Alejandro Vaquero, Jeannie T. Lee, Cristina Marín-García, Josema Castelló-García, Jay Tischfield
| Nature Verified
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan. Notably, SIRT7 preferentially localizes to the sex chromosomes.
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SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the mouse testis

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By Anna Guitart-Solanes, Mayra Romero, Andrés Gámez-García, Bryan A. Niedenberger, Norah Spears, Ignasi Roig, Christopher B Geyer, Alejandro Vaquero, Karen Schindler, Berta N. Vazquez, Irene Fernández-Duran, Cristina Madrid-Sandín
| Nature Verified
Abstract Reproductive aging is an increasing health concern that affects family planning and overall well-being. While extensively studied in females, the mechanisms driving male reproductive aging remain largely unexamined. Here, we found that mammalian Sirtuin 7 sustains spermatogenesis in an age-dependent manner.
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