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Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release

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By Stefania Monterisi, Sandy Chu, Jillian N. Simon, Besarte Vrellaku
| AHA/ASA Journals
Originally published13 Nov 2020https://doi.org/10.1161/CIRCULATIONAHA.120.046761Circulation. ;0 Abstract Background: Kinase oxidation is a critical signalling mechanism through which changes in the intracellular redox state alter cardiac function. In the myocardium, type-1 protein kinase A (PKARIα) can be reversibly oxidized, forming interprotein disulfide bonds within the holoenzyme complex.
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