Sandy Chu

1 Introduction Stillbirths are a significant global health issue, having been described as a neglected epidemic with an estimated 2.6 million stillbirths occurring annually [1]. In Australia, approximately seven in every 1000 babies are stillborn. Stillbirth is defined as a foetal death after 20 weeks' gestation or, when gestation is uncertain, a birthweight of 400 g or more [2, 3]. Stillbirths present a substantial personal and financial cost to families, healthcare workers and society.

1 Introduction Stillbirths are a significant global health issue, having been described as a neglected epidemic with an estimated 2.6 million stillbirths occurring annually [1]. In Australia, approximately seven in every 1000 babies are stillborn. Stillbirth is defined as a foetal death after 20 weeks' gestation or, when gestation is uncertain, a birthweight of 400 g or more [2, 3]. Stillbirths present a substantial personal and financial cost to families, healthcare workers and society.

Post-ischaemic metabolomic profiles We hypothesised that the protective phenotype observed in cmGch1 KO mice in response to IR injury could be due to altered cardiac metabolism, favouring glycolysis with downregulation of fatty acid oxidation. To investigate the effects of cardiomyocyte-specific deletion of Gch1 on the metabolic response to IR injury, we undertook a non-biased metabolomics analysis, using female mice as the effect on IR injury was more prominent.