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Articles by Beverly E. Sha
5′ leader defects drive persistent HIV-1 viremia on long-term ART
Abstract Traces of HIV-1 RNA can persist in plasma despite long-term suppressive antiretroviral therapy (ART). Some individuals develop nonsuppressible viremia (NSV), characterized by detectable HIV-1 RNA that raises concerns for virological failure, pathogenesis, and transmission. The sources of NSV remain poorly defined, in part due to limited tools to characterize plasma HIV-1 RNA.
An HIV-1 Reference Epitranscriptome
Abstract Post-transcriptional chemical modifications to RNA, or the epitranscriptome, play important roles in RNA metabolism, gene regulation, and human disease, including viral pathogenesis.
Canonical Wnts Mediate CD8+ T Cell Noncytolytic Anti-HIV-1 Activity and Correlate with HIV-1 Clinical Status
Jennillee Wallace, Srinivas D. Narasipura, Beverly E. Sha, Audrey L. French and Lena Al-Harthi J Immunol October 15, 2020, 205 (8) 2046-2055; DOI: https://doi.org/10.4049/jimmunol.1801379 Key Points CD8+ T cells release Wnts that suppress HIV transcription. Antagonizing Wnts abrogates CD8+ T cell noncytotoxic anti-HIV activity. Wnts correlate with HIV controller status. Abstract CD8+ T cells do not rely solely on cytotoxic functions for significant HIV control.
Canonical Wnts Mediate CD8+ T Cell Noncytolytic Anti-HIV-1 Activity and Correlate with HIV-1 Clinical Status
Jennillee Wallace, Srinivas D. Narasipura, Beverly E. Sha, Audrey L. French and Lena Al-Harthi J Immunol September 4, 2020, ji1801379; DOI: https://doi.org/10.4049/jimmunol.1801379 Key Points CD8+ T cells release Wnts that suppress HIV transcription. Antagonizing Wnts abrogates CD8+ T cell noncytotoxic anti-HIV activity. Wnts correlate with HIV controller status. Abstract CD8+ T cells do not rely solely on cytotoxic functions for significant HIV control.
The 2019 ACIP-Recommended Adult Immunization Schedule
Immunization guidelines for adults are routinely updated, and primary care clinicians should be aware of the most current immunization recommendations. Within the past 2 years, 2 new vaccines were approved by the US Food and Drug Administration (FDA) for adults.
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