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Bharani Muppavarapu on Muck Rack

Bharani Muppavarapu

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Articles

HNF1A is a novel BRD4 target and critical for BET-inhibitor response in pancreatic ductal adenocarcinoma

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By Kennedy Humphrey, Katherine Crawford, William Morris Verified, Evan Torres, Mark Long Verified, Jianxin Wang, Erik S. Knudsen, Agnieszka K. Witkiewicz, Ethan Abel, Bharani Muppavarapu, Melanie M. Mayberry
| Nature Verified
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an exceedingly lethal cancer that lacks actionable molecular drivers. We previously identified the transcription factor, HNF1A, as a novel driver of tumorigenesis, stemness, and metastasis in PDAC; however, HNF1A-targeting modalities do not currently exist.
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