Bhavisha Patel on Muck Rack

Bhavisha Patel

Verified
Seattle
As seen in: KCPQ-TV (Seattle, WA), Medium, Nature, Wiley Online Library, Change.org, Sky Sports, The Canadian Journal of Human Sexuality ( UTP), Redbrick (University of Birmingham), Annals of Vascular Surgery, Pharmacy Business, OM Yoga & Lifestyle Magazine
🏆 Emmy-winning Executive Producer of Sports and Special Projects at FOX Television Stations/@fox13seattle
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Articles

Imputing causality and clonal dynamics from single-cell transcriptomics in paroxysmal nocturnal hemoglobinuria

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By Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Fernanda Gutierrez-Rodrigues, Olga Rios, Jennifer Lotter, Sachiko Kajigaya, Jibran Durrani, Emma M. Groarke, Bhavisha Patel Verified, Neal Young, Lemlem Alemu, Diego Quinones Raffo, Ivana Darden
| Nature Verified
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) originates from hematopoietic stem cells (HSCs) harboring somatic mutations in the phosphatidylinositol glycan class A (PIGA) gene. Clonal expansion of PIGA-mutated cells occurs uniquely in the setting of bone marrow (BM) failure, but specific pathophysiologic mechanisms remain unclear. We performed single-cell RNA sequencing (scRNA-seq) of BM cells from patients with large (> 50%) and small (10–50%) PNH cell fractions.
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Hypomethylating agents in vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS): A systematic review

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By Fieke W. Hoff, Roochi Trikha, Emma M. Groarke, Bhavisha Patel Verified
| Wiley Online Library Verified
INTRODUCTION VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is an X-linked, systemic, haemato-inflammatory syndrome that was first described in 2020.1 VEXAS is a clonal disease caused by somatic mutations in the UBA1 gene that originate in a haematopoietic stem and progenitor cell (HSPC) but mostly affects the myeloid precursor cells.2 The UBA1 gene encodes the ubiquitin-activating enzyme, E1, that is essential for ubiquitin signalling, a process involved in protein...
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Closing the treatment gap in knee osteoarthritis - the GEKO trial begins

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By Raman Uberoi, Anjali Shah, Bhavisha Patel Verified, Loretta J Davies
| bjsacademy.com
Sarah Whittley Superficial venous intervention has transformed the treatment of varicose veins, offering patients minimally invasive solutions with excellent short-term outcomes. Yet, despite technical advances, an important question remains unresolved: Should pharmacological thromboprophylaxis be routinely prescribed to prevent postoperative deep vein thrombosis (DVT)?
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