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Bianca Bartl

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Articles

Regulation of somatic hypermutation by higher-order chromatin structure

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By Ursula E. Schoeberl, Johanna Fitz, Renan Valieris, Bernd Bauer, Daniel Malzl, Kimon Froussios, Julia Costea, Franziska Schmidt, Jeremy Pflaum, Johanna Albrecht, Eva-Maria Wiedemann, Adriana Garcia, Mihaela Peycheva, Marta Rizzi, Anton Goloborodko, Rushad Pavri, Bianca Bartl
| Cell Press Verified
Keywords somatic hypermutation human immunoglobulin heavy-chain locus antibody maturation transcription hub Tri-C PRO-seq chromatin architecture chromatin loop extrusion cohesin class switch recombination Introduction Higher-order chromatin architecture plays a crucial role in regulating biological processes by controlling the spatial organization of the genome and facilitating interactions between regulatory elements and target genes.1,2 A major physiological pathway requiring complex and...
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