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Bin Geng

As seen in: Nature, Wiley Online Library, Frontiers, MDPI, Physiological Research
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Articles by Bin Geng

Chromobox 3 assembles an epigenetic complex contributing to cystathionine γ-lyase–mediated protection against aortic aneurysm/dissection

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By Ying Zhao, Changting Cui, Huimin Gao, Yan Yao, Yaping Niu, Haizeng Zhang, Yuan Wang, Yuanzhen Lin, Zengxiang Dong, He Wu, Zhenzhen Chen, Bin Geng, Xiaodie Shao
| Nature Verified
Abstract Hydrogen sulfide (H₂S), generated by cystathionine γ-lyase (CSE), protects against aortic aneurysm and dissection (AAD), yet its role in extracellular matrix (ECM) regulation remains unclear. Here, we demonstrate that CSE expression is markedly attenuated in vascular smooth muscle cells (VSMCs) from human AAD specimens and AngII-induced male murine models. VSMC-specific Cse deletion exacerbated AAD formation.
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Laboratory biomarkers and radiographic osteolysis after total knee arthroplasty: a retrospective pilot study

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By Lifei Wang, Hefang Xiao, Jinming Liu, Haotian He, Bin Geng, Yayi Xia, Bao Xian
| Frontiers
Abstract Purpose: This study aimed to identify early risk factors for periprosthetic osteolysis after total knee arthroplasty (TKA) and establish clinically useful predictive biomarkers. Methods: A retrospective analysis was conducted on patients who underwent TKA at our institution between January 1, 2018, and October 31, 2023. Initially, 397 patients were screened, and 375 met the inclusion criteria after applying strict eligibility standards.
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Gut microbiota-derived metabolite isovalerylcarnitine modulates salt sensitivity of blood pressure and incident hypertension: a multicenter dietary salt intervention trial | Nature Communications

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By Zhennan Lin, Mengyao Liu, Jianxin Li, Bin Geng, Dongfeng Gu
| Nature Verified
Abstract This study aims to investigate the roles of gut microbiota and plasma metabolites in salt sensitivity (SS) of blood pressure (SSBP) and hypertension. A 23-day, multicenter, dietary salt intervention trial (the MetaSalt study) recruited 528 participants who underwent a baseline observation, low-salt, and high-salt interventions. SSBP was assessed and used as the primary outcome, and fecal shotgun metagenome and plasma targeted metabolome were measured.
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Do Age and Timing Influence the Outcomes of Single‐stage Reconstruction of Multiple Ligament Knee Injuries? 5‐10 Years Follow Up

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By Jinwen He, Bin Geng, Peng Xu, Yayi Xia
| Wiley Online Library Verified
Introduction Multiple ligament knee injuries (MLKIs) have long been a formidable challenge, garnering attention due to their intricacy and diversity.1-3 Such injuries typically involve damage to multiple ligaments within the knee, including the anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), medial collateral ligament (MCL), lateral collateral ligament (LCL), or posterolateral corner (PLC), making diagnosis and treatment a challenging endeavor.4, 5 Surgical reconstruction...
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Effect of CaO-MgO-FeO-SiO2-xNa2O Slag System on Converter Dephosphorization

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By Bin Geng, Dongping Zhan, Zhouhua Jiang, Yongkun Yang
| MDPI
Abstract : Na2O is an alkaline oxide, which can significantly improve the dephosphorization ability of converter slag. The effect of Na2O on the dephosphorization of converter slag was analyzed with a high-temperature dephosphorization experiment in a MoSi2 resistance furnace. We found that the dephosphorization rate increased with the increase of (Na2O) in the dephosphorization slag.
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