Zengxiang Dong on Muck Rack

Zengxiang Dong

As seen in: Nature
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Articles

Chromobox 3 assembles an epigenetic complex contributing to cystathionine γ-lyase–mediated protection against aortic aneurysm/dissection

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By Ying Zhao, Changting Cui, Huimin Gao, Yan Yao, Yaping Niu, Haizeng Zhang, Yuan Wang, Yuanzhen Lin, Zengxiang Dong, He Wu, Zhenzhen Chen, Bin Geng, Xiaodie Shao
| Nature
Abstract Hydrogen sulfide (H₂S), generated by cystathionine γ-lyase (CSE), protects against aortic aneurysm and dissection (AAD), yet its role in extracellular matrix (ECM) regulation remains unclear. Here, we demonstrate that CSE expression is markedly attenuated in vascular smooth muscle cells (VSMCs) from human AAD specimens and AngII-induced male murine models. VSMC-specific Cse deletion exacerbated AAD formation.
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Histone acetyltransferase 1 promotes postinfarction inflammatory response by regulation of monocyte histone succinylation - Nature Communications

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By Zengxiang Dong
| Nature
Abstract Early activation and phenotypic transformation of monocytes and macrophages are essential for inflammatory activities and tissue repair following myocardial infarction (MI). However, the involvement of histone succinylation in monocyte phenotypic regulation during MI remains poorly understood.
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